Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life
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چکیده
منابع مشابه
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
Cell surface proteolysis is essential for communication between cells and results in the shedding of membrane-protein ectodomains. However, physiological substrates of the contributing proteases are largely unknown. We developed the secretome protein enrichment with click sugars (SPECS) method, which allows proteome-wide identification of shedding substrates and secreted proteins from primary c...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2019
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2019.06.3918